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Unit I: Biomolecules And Bioenergetics

Syllabus Topics to Learn

Biomolecules: Introduction

Classification

Chemical nature and biological role of carbohydrate

Lipids

Nucleic acids

Amino acids and proteins. Bioenergetics: Concept of free energy

Endergonic and exergonic reaction

Relationship between free energy

Enthalpy and entropy; Redox potential. Energy rich compounds; classification; biological significances of ATP and cyclic AMP.

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Unit II: Carbohydrate Metabolism And Biological Oxidation

Syllabus Topics to Learn

Carbohydrate metabolism: Glycolysis- Pathway

Energetics and significance. Gluconeogenesis- Pathway and its significance. Citric acid cycle- Pathway

Energetics and significance. HMP shunt and its significance- Glucose-6-Phosphate dehydrogenase (G6PD) deficiency. Glycogen metabolism Pathways and glycogen storage diseases (GSD). Hormonal regulation of blood glucose level and Diabetes mellitus. Biological oxidation: Electron transport chain (ETC) and its mechanism. Oxidative phosphorylation & its mechanism and substrate level phosphorylation. Inhibitors ETC and oxidative phosphorylation/Uncouplers.

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Unit III: Lipid Metabolism And Amino Acid Metabolism

Syllabus Topics to Learn

Lipid metabolism: β-Oxidation of saturated fatty acid (Palmitic acid). Formation and utilization of ketone bodies; ketoacidosis. De novo synthesis of fatty acids (Palmitic acid). Biological significance of cholesterol and conversion of cholesterol into bile acids

Steroid hormone and vitamin D. Disorders of lipid metabolism: Hypercholesterolemia

Atherosclerosis

Fatty liver and obesity. Amino acid metabolism: General reactions of amino acid metabolism. Transamination

Deamination and decarboxylation

Urea cycle and its disorders. Catabolism of phenylalanine and tyrosine and their metabolic disorders (Phenylketonuria, Albinism, Alkaptonuria, Tyrosinemia). Synthesis and significance of biological substances: 5-HT

Melatonin

Dopamine

Noradrenaline

Adrenaline. Catabolism of heme; hyperbilirubinemia and jaundice.

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Unit IV: Nucleic Acid Metabolism And Genetic Information Transfer

Syllabus Topics to Learn

Nucleic acid metabolism and genetic information transfer Biosynthesis of purine and pyrimidine nucleotides. Catabolism of purine nucleotides and Hyperuricemia and Gout disease. Organization of mammalian genome. Structure of DNA and RNA and their functions DNA replication (semi conservative model) Transcription or RNA synthesis. Genetic code

Translation or Protein synthesis and inhibitors.

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Unit V: Enzymes And Coenzymes

Syllabus Topics to Learn

Enzymes: Introduction

Properties

Nomenclature and IUBMB classification of enzymes. Enzyme kinetics (Michaelis-Menten plot, Line-Weaver Burke plot) Enzyme inhibitors with examples. Regulation of enzymes: enzyme induction and repression

Allosteric enzymes regulation. Coenzymes: Structure and biochemical functions. Therapeutic and diagnostic applications of enzymes and isoenzymes.

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Subject Overview

Course Code BP203T

Syllabus Status 100% PCI Aligned

Total Units 5 Units

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