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Unit I: Antibiotics, β-Lactam Antibiotics, Aminoglycosides And Tetracycline

Syllabus Topics to Learn

Antibiotics: Historical background

Nomenclature

Stereochemistry

Structure activity relationship

Chemical degradation classification and important products of the following classes. β-Lactam antibiotics: Penicillin

Cephalosporin

β-Lactamase inhibitors

Monobactams. Aminoglycosides: Streptomycin

Neomycin

Kanamycin. Tetracycline: Tetracycline

Oxytetracycline

Chlortetracycline

Minocycline

Doxycycline.

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Unit II: Antibiotics

Syllabus Topics to Learn

Antibiotics: Historical background

Nomenclature

Stereochemistry

Structure activity relationship

Chemical degradation classification and important products of the following classes. Macrolide: Erythromycin Clarithromycin

Azithromycin. Miscellaneous: Chloramphenicol*

Clindamycin. Prodrugs: Basic concepts and application of prodrugs design. Antimalarial: Etiology of malaria. Quinolines: SAR

Quinine sulphate

Chloroquine*

Amodiaquine

Primaquine phosphate

Pamaquine*

Quinacrine hydrochloride

Mefloquine. Biguanides and dihydro triazines: Cycloguanil pamoate

Proguanil. Miscellaneous: Pyrimethamine

Artesunate

Artemether

Atovaquone.

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Unit III: Anti-Tubercular, Urinary Tract Anti-Infective And Antiviral Agents

Syllabus Topics to Learn

Anti-tubercular Agents: Synthetic anti tubercular agents: Isoniazid*

Ethionamide

Ethambutol

Pyrazinamide

Para amino salicylic acid.* Ant-tubercular antibiotics: Rifampicin

Rifabutin

Cycloserine

Streptomycin

Capreomycin sulphate. Urinary tract anti-infective agents: Quinolones: SAR of quinolones

Nalidixic Acid

Norfloxacin

Enoxacin

Ciprofloxacin*

Ofloxacin

Lomefloxacin

Sparfloxacin

Gatifloxacin

Moxifloxacin. Miscellaneous: Furazolidine

Nitrofurantoin*

Methanamine. Antiviral agents: Amantadine hydrochloride

Rimantadine hydrochloride

Idoxuridine trifluoride

Acyclovir*

Ganciclovir

Zidovudine

Didanosine

Zalcitabine

Lamivudine

Loviride

Delavirdine

Ribavirin

Saquinavir

Indinavir

Ritonavir.

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Unit IV: Antifungal, Anti-Protozoal, Anthelmintic, Sulphonamides and Sulfones

Syllabus Topics to Learn

Antifungal agents: Antifungal antibiotics: Amphotericin-B

Nystatin

Natamycin

Griseofulvin. Synthetic Antifungal agents: Clotrimazole

Econazole

Butoconazole

Oxiconazole Tioconazole

Miconazole*

Ketoconazole

Terconazole

Itraconazole

Fluconazole

Naftifine hydrochloride

Tolnaftate.* Anti-protozoal Agents: Metronidazole*

Tinidazole

Ornidazole

Diloxanide

Iodoquinol

Pentamidine Isethionate

Atovaquone

Eflornithine. Anthelmintic: Diethylcarbamazine citrate*

Thiabendazole

Mebendazole*

Albendazole

Niclosamide

Oxamniquine

Praziquantel

Ivermectin. Sulphonamides and Sulfones: Historical development

Chemistry

Classification and SAR of Sulfonamides: Sulphamethizole

Sulfisoxazole

Sulphamethizine

Sulfacetamide*

Sulphapyridine

Sulfamethoxazole*

Sulphadiazine

Mefenide acetate

Sulfasalazine. Folate reductase inhibitors: Trimethoprim*

Cotrimoxazole. Sulfones: Dapsone*.

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Unit V: Introduction To Drug Design And Combinatorial Chemistry

Syllabus Topics to Learn

Introduction to Drug Design: Various approaches used in drug design. Physicochemical parameters used in quantitative structure activity relationship (QSAR) such as partition coefficient

Hammett’s electronic parameter

Taft’s steric parameter and Hansch analysis. Pharmacophore modeling and docking techniques. Combinatorial Chemistry: Concept and applications of combinatorial Chemistry: Solid phase and solution phase synthesis.

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Subject Overview

Course Code BP601T

Syllabus Status 100% PCI Aligned

Total Units 5 Units

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